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BACKGROUND
To reduce oral cancer mortality, an organized, population‐based screening program for the early detection of oral premalignancy and oral cancer was designed for high‐risk individuals with habits of betel quid chewing, cigarette smoking, or both. The objective of this report was to evaluate the long‐term effectiveness of this program in reducing the incidence of advanced disease and deaths...
BACKGROUND
Prostate cancer (PCa) outcomes are impacted by socioeconomic and biologic factors. Ethnicity plays a role in the former, but little is known about the responsiveness of metastatic PCa to androgen‐deprivation therapy (ADT) among races.
METHODS
The Surveillance, Epidemiology, and End Results (SEER) registry was used to identify men who were diagnosed with distant, de novo, metastatic PCa...
BACKGROUND
Novel fusion transcripts (FTs) caused by chromosomal rearrangement are common factors in the development of cancers. In the current study, the authors used massively parallel RNA sequencing to identify new FTs in colon cancers.
METHODS
RNA sequencing (RNA‐Seq) and TopHat‐Fusion were used to identify new FTs in colon cancers. The authors then investigated whether the novel FT nuclear...
BACKGROUND
Skeletal‐related events (SREs) are common complications of bone metastatic castration‐resistant prostate cancer (mCRPC). To the authors' knowledge, there are limited data regarding which factors predict SREs. The authors identified risk factors for SREs in men with bone mCRPC using characteristics commonly available in the medical record.
METHODS
Data from 454 patients with nonmetastatic...
The treatment of locally advanced rectal cancer (LARC) has benefited from improved surgical techniques and from the implementation of neoadjuvant chemoradiotherapy (CRT), which have markedly decreased the rates of local recurrence. However, distant metastatic disease remains the most significant cause of death for these patients. Although adjuvant chemotherapy (ChT) after neoadjuvant CRT and definitive...
BACKGROUND
Recent treatment advances have greatly improved the prognosis of patients with multiple myeloma. However, some of these newer, more effective treatments are intensive and expensive and their use remains low, particularly among black patients.
METHODS
In the current study, the authors reviewed the use patterns of stem cell transplantation and bortezomib using the Surveillance, Epidemiology,...
BACKGROUND
The outcomes of patients with unresected anaplastic thyroid carcinoma (ATC) from the National Cancer Data Base (NCDB) were assessed, and potential correlations were explored between radiation therapy (RT) dose and overall survival (OS).
METHODS
The study cohort was comprised of patients who underwent either no surgery or grossly incomplete resection. Correlates of OS were explored using...
BACKGROUND
Human papillomavirus (HPV) is a well‐established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers of women and nonwhites in studies to date, sex and racial/ethnic differences in prognosis have not been well explored. In this study, survival differences were explored by the tumor HPV status among 1) patients with OPSCCs by sex and race and...
BACKGROUND
Out‐of‐pocket expenditures are thought to be an important barrier to the receipt of cancer preventive services, especially for those of a lower socioeconomic status (SES). The Affordable Care Act (ACA) eliminated out‐of‐pocket expenditures for recommended services, including mammography and colonoscopy. The objective of this study was to determine changes in the uptake of mammography and...
BACKGROUND
Nucleophosmin 1 (NPM1) is a nucleocytoplasmic shuttling protein mainly localized in the nucleolus. NPM1 is frequently mutated in acute myeloid leukemia (AML). NPM1c oligomerizes with wild‐type nucleophosmin 1 (wt‐NPM1), and this leads to its continuous cytoplasmic delocalization and contributes to leukemogenesis. Recent studies have shown that Cytoplasmic NPM1 (NPM1c) degradation leads...
BACKGROUND
Screening for colorectal cancer (CRC) has been successful in decreasing the incidence and mortality from CRC. Although new screening tests have become available, their relative impact on CRC outcomes remains unexplored. This study compares the outcomes of various screening strategies on CRC outcomes.
METHODS
A Markov model representing the natural history of CRC was built and validated...
BACKGROUND
Single‐modality radiotherapy is considered a standard‐of‐care option for certain stage III, T1‐2N1 head and neck squamous cell carcinomas (HNSCCs). The role of concomitant chemoradiation is not well established because there have been no studies comparing chemoradiation with radiation alone in this population.
METHODS
This study analyzed patients in the National Cancer Data Base with...
BACKGROUND
Tumor response to neoadjuvant chemotherapy using the regimen of cisplatin and 5‐fluorouracil could define high‐risk patients with locoregionally advanced nasopharyngeal carcinoma (NPC). However, the regimen of docetaxel, cisplatin, and 5‐fluorouracil (TPF) appears to be more effective than the regimen of cisplatin and 5‐fluorouracil. Therefore, one needs to redefine the high‐risk subpopulation...
BACKGROUND
Stereotactic body radiation therapy (SBRT) for localized prostate cancer involves high‐dose‐per‐fraction radiation treatments. Its use is increasing, but concerns remain about treatment‐related toxicity. The authors assessed the incidence and predictors of a global decline in health‐related quality of life (HRQOL) after prostate SBRT.
METHODS
From 2008 to 2014, 713 consecutive men with...
There has been limited success in identifying prognostic biomarkers in prostate cancer. A partial explanation may be that insufficient emphasis has been put on clearly defining what type of marker or patient category a biomarker study aims to identify and how different cohort characteristics affect the ability to identify such a marker. In this article, the authors put forth the ABC model of prostate...
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